Site(s) of infection | Definitive therapy | Duration of therapy |
GA <35 weeks | GA ≥35 weeks |
Bacteremia/sepsis/pneumonia | - PNA ≤7 days
- Penicillin G 50,000 units/kg per dose IV every 12 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 12 hours
| - PNA ≤7 days
- Penicillin G 50,000 units/kg per dose IV every 12 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 10 days |
- PNA >7 days
- Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 75 mg/kg per dose IV every 12 hours
| - PNA >7 days
- Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 10 days |
Meningitis | - PNA ≤7 days
- Penicillin G 150,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 100 mg/kg per dose IV every 8 hours
| - PNA ≤7 days
- Penicillin G 150,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 100 mg/kg per dose IV every 8 hours
| 14 days* |
- PNA >7 days
- Penicillin G 125,000 units/kg per dose IV every 6 hours
- Alternative – Ampicillin 75 mg/kg per dose IV every 6 hours
| - PNA >7 days
- Penicillin G 125,000 units/kg per dose IV every 6 hours
- Alternative – Ampicillin 75 mg/kg per dose IV every 6 hours
| 14 days* |
Other focal infections (dosing is for term infants >7 days old since these infections typically occur beyond day 7 after birth) |
Cellulitis/adenitis | - Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 10 to 14 days |
Septic arthritis | - Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 14 to 21 days |
Osteomyelitis | - Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 21 to 28 days |
Urinary tract infection | - Penicillin G 50,000 units/kg per dose IV every 8 hours
- Alternative – Ampicillin 50 mg/kg per dose IV every 8 hours
| 10 days |