Abnormalities of DNA metabolism |
Vitamin B12 (cobalamin) deficiency |
Folate deficiency |
Drugs |
Antiretroviral therapies for HIV infection (eg, zidovudine) |
Azathioprine or 6-mercaptopurine |
Capecitabine |
Cladribine |
Cytosine arabinoside |
Hydroxyurea |
Imatinib, sunitinib |
Methotrexate |
Shift to immature or stressed red cells |
Reticulocytosis |
Action of erythropoietin - skip macrocytes, stress erythrocytosis |
Aplastic anemia/Fanconi anemia |
Pure red cell aplasia |
Primary bone marrow disorders |
Myelodysplastic syndromes |
Congenital dyserythropoietic anemias |
Some sideroblastic anemias |
Large granular lymphocyte (LGL) leukemia |
Lipid abnormalities |
Liver disease |
Hypothyroidism |
Mechanism unknown |
Alcohol abuse |
Multiple myeloma and other plasma cell disorders |
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