LAD I | LAD II | LAD III | |
Clinical manifestation | |||
Recurrent severe infections | +++ | + | +++ |
Neutrophilia | |||
basal | + | +++ | ++ |
with infection | +++ | +++ | +++ |
Periodontitis | ++ | ++ | ? |
Skin infection | ++ | + | ++ |
Delayed separation of the umbilical cord | +++ | - | + |
Developmental abnormalities | - | +++ | |
Bleeding tendency | - | - | +++ |
Laboratory findings | |||
CD18 expression | ↓ ↓ ↓ or absent | NL | NL |
SLeX expression | NL | Absent | NL |
Neutrophil motility | ↓ ↓ ↓ | ↓ ↓ | ↓ ↓ |
Neutrophil rolling | NL | ↓ ↓ ↓ | NL |
Neutrophil adherence | ↓ ↓ ↓ | ↓ | ↓ ↓ ↓ |
Opsonophagocytic activity | ↓ | NL | NL |
T and B cell function | ↓ | NL | ? |
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