Fibroblast response | Mediators |
Increased fibroblast chemotaxis | TGF-beta, IL-4, TNF-alpha and beta, PDGF, IFN gamma, ET-1 |
Increased fibroblast proliferation | IL-1 alpha and beta, bFGF, aFGF, PDGF, IL-6, EGF, TGF-beta (via PDGF), ET-1, IL-17 |
Increased collagen synthesis | TGF-β, IL-1 alpha and beta, IL-4, IGF |
Decreased collagen synthesis | bFGF, IFN gamma and alpha, relaxin, EGF, TNF-alpha |
Increased collagenase synthesis | IL-1 alpha and beta, bFGF, TNF-alpha and beta |
Decreased collagen synthesis | TGF-beta |
Increased TIMP synthesis | IL-1 alpha and beta, TGF-beta |
Decreased TIMP synthesis | IL-6 |
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