Activation fragment | Number on a single cell | Notes |
C4b | 2.5 million | Cleavage by C1s generates C4b; C4b covalently binds to target |
C4bC2b | 0.5 million | C3 convertase; one in five C4bs forms a convertase |
C3b | 20 million | Approximately 10 times more C3b than C4b attaches to target (opsonization) |
C5b-C9 | 1 million | Membrane perturbation including lysis by the membrane attack complex |
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