Drug | Adult oral total daily dose (mg)* | Comparative potency (mg)¶ | Onset after oral dose (hours) | Metabolism | Elimination half-life (hours)Δ |
Alprazolam | 0.5 to 6 | 0.5 | 1 | CYP3A4 to minimally active metabolites. | 11 to 15 16 (older adults) 20 (hepatic impairment) 22 (obesity) |
Alprazolam extended release | 0.5 to 6 once daily | 0.5 | 1 | ||
Bromazepamפ | 6 to 30 | 7.5 | 1 | CYP1A2. No active metabolite. | 8 to 20 |
Chlordiazepoxide§ | 5 to 100 | 10 | 1 | CYP3A4 to active metabolites. | 30 to 100 Prolonged in older adults and hepatic impairment |
Clonazepam | 0.5 to 4 | 0.25 to 0.5 | 0.5 to 1 | CYP3A4. No active metabolite. | 18 to 50 |
Clorazepate | 15 to 60 | 7.5 | 0.5 to 1 | CYP3A4 to active metabolite. | 36 to 200 |
Diazepam | 4 to 40 | 5 | 0.25 to 0.5 | CYP2C19 and 3A4 to active metabolites. | 50 to 100 Prolonged in older adults and renal or hepatic impairment |
Lorazepam immediate release | 0.5 to 6 0.5 to 4 (hypnotic) | 1 | 0.5 to 1 | Non-CYP glucuronidation in liver. No active metabolite. | 10 to 14 |
Lorazepam extended release | 1 to 6 mg¥ | 1 | 0.5 to 1 | Non-CYP glucuronidation in liver. No active metabolite. | 13 to 27 |
Oxazepam | 30 to 120 15 to 30 (hypnotic) | 15 to 30 | 1 to 2 | Non-CYP glucuronidation in liver. No active metabolite. | 5 to 15 |
Prazepamפ | 15 to 60 | 15 | 2 to 3 | CYP3A4 to active metabolites. | 30 to 200 Prolonged in older adults |
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