Antibody | Disease subtype | Additional features |
Antinuclear antibody (ANA) | Type 1 | Most common antibodies in type 1 disease |
Antismooth muscle antibody (ASMA) | Type 1 | ASMA titers of 1:320 or greater generally reflect the presence of AAA |
Antiactin antibody (AAA) | Type 1 | Not routinely measured in North American laboratories |
Antimitochondrial antibody (AMA) | Type 1 | More specific for primary biliary cholangitis |
Atypical perinuclear antineutrophil cytoplasmic antibody (p-ANCA) | Type 1 | Also found in patients with primary sclerosing cholangitis |
Anti-soluble liver antigen/liver pancreas antibodies (anti-SLA/LP) | Type 1 and type 2 | More common in children with type 2 disease |
Anti-DNA antibodies (single stranded DNA [ssDNA] and double-stranded DNA [dsDNA]) | Type 1 and type 2 | Anti-dsDNA antibody is commonly associated with systemic lupus erythematosus |
Anti-liver kidney microsomal-1 antibody (ALKM-1) | Type 2 | Occurs mostly in type 2 disease |
Anti-liver cytosol-1 antibody (ALC-1) | Type 2 | May occur in conjunction with ALKM-1 |
Anti-liver kidney microsomal-3 antibody (ALKM-3) | Type 2 | Rarely present |
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