Return To The Previous Page
Buy a Package
Number Of Visible Items Remaining : 3 Item

Drugs that potentiate the action of sulfonylureas

Drugs that potentiate the action of sulfonylureas
Inhibition of membrane transporters
Clarithromycin, fluoroquinolones (eg, levofloxacin), verapamil
Decreased hepatic CYP2C metabolism

Antiinfectives: Clarithromycin, fluconazole, metronidazole, isoniazid, miconazole (oral), trimethoprim-sulfamethoxazole (and other sulfonamide antibiotics), voriconazole

Other: Amiodarone, capecitabine, cimetidine, fluorouracil, fluvastatin, gemfibrozil (and other fibric acid derivatives), losartan, MAO inhibitors*, mifepristone, nicardipine, omeprazole, ticagrelor, warfarin
Intrinsic hypoglycemic activity
Alcohol, androgens (anabolic steroids), beta-blockers (variable effects), fluoroquinolones, MAO inhibitors*, pentamidine, quinine, salicylates, other antihyperglycemic drugs
Decreased renal excretion
Allopurinol, probenecid, salicylates
Masks autonomic signs of hypoglycemia
Beta-blockers
Examples of drugs that may potentiate the hypoglycemic effect of sulfonylureas. Specific interactions of sulfonylureas may be analyzed by use of the drug interaction program included within UpToDate.

MAO inhibitors: monoamine oxidase inhibitors.

* MAO inhibitors include: Isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine (antineoplastic), rasagiline, selegiline, Syrian Rue (hallucinogen), tedizolid, tranylcypromine.

¶ Frequently encountered salicylates include: Aspirin, bismuth subsalicylate, salsalate.
Graphic 64887 Version 8.0

Do you want to add Medilib to your home screen?