Inhibition of membrane transporters |
Clarithromycin, fluoroquinolones (eg, levofloxacin), verapamil |
Decreased hepatic CYP2C metabolism |
Antiinfectives: Clarithromycin, fluconazole, metronidazole, isoniazid, miconazole (oral), trimethoprim-sulfamethoxazole (and other sulfonamide antibiotics), voriconazole Other: Amiodarone, capecitabine, cimetidine, fluorouracil, fluvastatin, gemfibrozil (and other fibric acid derivatives), losartan, MAO inhibitors*, mifepristone, nicardipine, omeprazole, ticagrelor, warfarin |
Intrinsic hypoglycemic activity |
Alcohol, androgens (anabolic steroids), beta-blockers (variable effects), fluoroquinolones, MAO inhibitors*, pentamidine, quinine, salicylates¶, other antihyperglycemic drugs |
Decreased renal excretion |
Allopurinol, probenecid, salicylates¶ |
Masks autonomic signs of hypoglycemia |
Beta-blockers |
MAO inhibitors: monoamine oxidase inhibitors.
* MAO inhibitors include: Isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine (antineoplastic), rasagiline, selegiline, Syrian Rue (hallucinogen), tedizolid, tranylcypromine.
¶ Frequently encountered salicylates include: Aspirin, bismuth subsalicylate, salsalate.Do you want to add Medilib to your home screen?