Mandatory major criteria |
|
Other major criteria (one required) |
|
Minor criteria |
|
Other symptoms and signs | Clubbing, weight loss, hyperhidrosis, pulmonary hypertension/restrictive lung disease, thrombotic diatheses, diarrhea, low vitamin B12 values |
POEMS: Polyneuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes.
* There is a Castleman disease variant of POEMS syndrome that occurs without evidence of a clonal plasma cell disorder that is not accounted for in this table. This entity should be considered separately.
¶ Because of the high prevalence of diabetes mellitus and thyroid abnormalities, this diagnosis alone is not sufficient to meet this minor criterion.
Δ Approximately 50% of patients will have bone marrow changes that distinguish it from a typical MGUS or myeloma bone marrow.[1] Anemia and/or thrombocytopenia are distinctively unusual in this syndrome unless Castleman disease is present.From: Dispenzieri A. POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management. Am J Hematol 2021; 96:872. https://onlinelibrary.wiley.com/doi/10.1002/ajh.26240. Copyright © 2021 Wiley Periodicals, LLC. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: permissions@wiley.com or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).
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