Endomicroscopic image of neoplasia in Barrett's esophagus

Endomicroscopic image of neoplasia arising from Barrett's esophagus (Panel A) and benign Barrett's metaplasia (Panel B). Cancerous tissue shows a loss of epithelial structures. The epithelium becomes dark and the vasculature is irregular with leakage of fluorescein. Benign mucosa is characterized by a more tubular shaped pattern with a regular and constant width of the epithelial layer. In addition, goblet cells (dark spots within the epithelial layer) can be clearly identified.