Regimen* | Irinotecan | Oxaliplatin | Leucovorin¶ | Fluorouracil/capecitabine | Schedule |
FOLFIRI[1] | 180 mg/m2 day 1 | 400 mg/m2 over two hours day 1 | Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 to 3000 mg/m2Δ over 46 hours, continuous infusion | Every two weeks | |
Douillard regimen[2] | 180 mg/m2 day 1 | 200 mg/m2 leucovorin over two hours days 1 and 2 before fluorouracil | Fluorouracil 400 mg/m2 bolus then 600 mg/m2 over 22 hours days 1 and 2 | Every two weeks | |
FOLFOX 4[3] | 85 mg/m2 day 1 | 400 mg/m2 over two hours days 1 and 2 before fluorouracil◊ | Fluorouracil 400 mg/m2 bolus, then 600 mg/m2 over 22 hours days 1 and 2 | Every two weeks | |
FOLFOX 6[1] | 100 mg/m2 day 1 | 400 mg/m2 over two hours day 1 | Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 to 3000 mg/m2Δ over 46 hours, continuous infusion | Every two weeks | |
Modified FOLFOX 6[4,5] | 85 mg/m2 day 1 | 350 mg total dose over two hours day 1 | Fluorouracil 400 mg/m2 bolus day 1, followed by 2400 mg/m2 over 46 hours | Every two weeks | |
FOLFOX 7[6] | 130 mg/m2 day 1 | 400 mg/m2 over two hours day 1 | Fluorouracil 400 mg/m2 bolus, then 2400 mg/m2 over 46 hours | Every two weeks | |
Modified FOLFOX 7[7] (Optimox) | 100 mg/m2 day 1 | 400 mg/m2 over two hours day 1 | Fluorouracil 3000 mg/m2 over 46 hours | Every two weeks | |
Modified FOLFOX 7[8] (CONcePT)§ | 85 mg/m2 day 1 | 200 mg/m2 over two hours day 1 | Fluorouracil 2400 mg/m2 over 46 hours | Every two weeks | |
XELOX[5] | 130 mg/m2 day 1 | Capecitabine 1000 mg/m2 orally twice per day on days 1 to 14 | Every three weeks | ||
FOLFOXIRI[9] | 165 mg/m2 day 1 | 85 mg/m2 day 1 | 400 mg/m2 leucovorin over two hours day 1 | Fluorouracil 3200 mg/m2 over 48 hours | Every two weeks |
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