Variation in pharmacokinetics of insulin detemir among 6 individuals given the same dose on 4 separate occasions (note significant peak effect at 8 to 12 hours and duration well short of 24 hours in some patients).
GIR: glucose infusion rate.
Data from: Heist T, Nosek L, Ronn BB, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes 2004; 53:1614.