To be fully effective, the medications must be injected directly into one of the penile erectile bodies, the corporus cavernosum. The medication will diffuse over to the other side of the penis so that symmetrical erection is achieved. A cross-section of the penis shows the relationship of the site of injection to the corpora cavernosae. Most men use an insulin syringe with a 26- to 30-gauge, half-inch needle.