Granulomatous diseases | Diagnostic tests |
Infections | |
Mycobacterial | |
Tuberculosis (M. tuberculosis) | PPD, CXR, QFT-G, AFB smear and culture |
Leprosy (M. leprae) | Skin smear or biopsy, PCR |
Atypical mycobacterial (eg, M. chelonei) | AFB smear and culture |
Treponemal | |
Syphilis | RPR, FTA-ABS |
Bacterial | |
Rhinoscleroma (Klebsiella rhinoscleromatis) | Culture |
Fungal | |
Histoplasmosis (Histoplasma capsulatum) | Special stains, culture, serology |
Protozoan | |
Leishmaniasis (Leishmania braziliensis) | Skin smear or aspirate, PCR, biopsy showing intra and extracellular Leishman bodies |
Rhinosporidiosis (Rhinosporidium seeberi) | Biopsy showing granulomas and typical sporangia |
Vasculitides | |
Granulomatosis with polyangiitis (Wegener's) | ANCA, biopsy |
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) | Peripheral eosinophilia, ANCA, biopsy |
Malignancy | |
Lethal midline granulomatosis (extranodal NK/T cell lymphoma) | Biopsy showing polymorphous lymphoid infiltrate; immunophenotype positive for CD2, surface CD3, CD56; clonal EBV genomes present |
Nonkeratinizing nasopharyngeal carcinoma | Biopsy shows an epithelial neoplasm with a dense lymphoplasmacytic infiltrate (predominantly T cells); associated with EBV infection |
Other | |
Sarcoidosis | Biopsy showing noncaseating granulomas, CXR |
Cocaine-induced midline destructive lesion | History of cocaine use |
Granulomatous rosacea | Granulomatous perifolliculitis |
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