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CO2 dissociation curve

CO2 dissociation curve

Carbon dioxide content (the sum of the amount of CO2 bound to hemoglobin and dissolved in plasma) is plotted as a function of the PaCO2 in the blood. Note that the relationship is relatively linear over the physiological range of PaCO2.

Because of the relatively linear shape of the PaCO2 versus CO2 content graph, hyperventilating a normal unit and reducing the PaCO2 in the blood from that unit can compensate for the elevated CO2 content of the blood leaving a poorly ventilated unit.
Reproduced with permission from: Schwartzstein RM, Parker MJ. The gas exchanger: Matching ventilation and perfusion. In: Respiratory Physiology: A Clinical Approach, Lippincott Williams & Wilkins 2005. Copyright © 2005 Wolters Kluwer Health, Inc.
Graphic 63166 Version 3.0