Schematic representation of the ileal brake where exposure of the distal ileum to fat and/or unabsorbed nutrients decreases gastric emptying, pancreatic secretion, and bowel motility. This response is mediated, in part, by peptide YY.
Modified from: Mannon P, Taylor IL. The Pancreatic Polypeptide Family. In: Gut Peptides, Biochemistry and Physiology, Walsh JH, Dockray JG (Eds), Raven Press Ltd, New York 1994. p.341.