Primary tumor (T)* | |||||
TX | Primary tumor cannot be assessed | ||||
T0 | No evidence of primary tumor | ||||
Tis | High-grade dysplasia¶ | ||||
T1 | Tumor invades lamina propria, muscularis mucosae, or submucosa | ||||
T1a | Tumor invades lamina propria or muscularis mucosae | ||||
T1b | Tumor invades submucosa | ||||
T2 | Tumor invades muscularis propria | ||||
T3 | Tumor invades adventitia | ||||
T4 | Tumor invades adjacent structures | ||||
T4a | Resectable tumor invading pleura, pericardium, or diaphragm | ||||
T4b | Unresectable tumor invading other adjacent structures, such as aorta, vertebral body, trachea, etc. | ||||
Regional lymph nodes (N)Δ | |||||
NX | Regional lymph node(s) cannot be assessed | ||||
N0 | No regional lymph node metastasis | ||||
N1 | Metastasis in 1 to 2 regional lymph nodes | ||||
N2 | Metastasis in 3 to 6 regional lymph nodes | ||||
N3 | Metastasis in seven or more regional lymph nodes | ||||
Distant metastasis (M) | |||||
M0 | No distant metastasis | ||||
M1 | Distant metastasis | ||||
Histologic grade (G) | |||||
GX | Grade cannot be assessed - stage grouping as G1 | ||||
G1 | Well differentiated | ||||
G2 | Moderately differentiated | ||||
G3 | Poorly differentiated | ||||
G4 | Undifferentiated - stage grouping as G3 squamous | ||||
Anatomic stage/prognostic groups | |||||
Squamous cell carcinoma◊ | |||||
Stage | T | N | M | Grade | Tumor location§ |
0 | Tis (HGD) | N0 | M0 | 1, X | Any |
IA | T1 | N0 | M0 | 1, X | Any |
IB | T1 | N0 | M0 | 2 to 3 | Any |
T2-3 | N0 | M0 | 1, X | Lower, X | |
IIA | T2-3 | N0 | M0 | 1, X | Upper, middle |
T2-3 | N0 | M0 | 2 to 3 | Lower, X | |
IIB | T2-3 | N0 | M0 | 2 to 3 | Upper, middle |
T1-2 | N1 | M0 | Any | Any | |
IIIA | T1-2 | N2 | M0 | Any | Any |
T3 | N1 | M0 | Any | Any | |
T4a | N0 | M0 | Any | Any | |
IIIB | T3 | N2 | M0 | Any | Any |
IIIC | T4a | N1-2 | M0 | Any | Any |
T4b | Any | M0 | Any | Any | |
Any | N3 | M0 | Any | Any | |
IV | Any | Any | M1 | Any | Any |
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