NSAIDs that preferentially inhibit COX-1 and cross-react with aspirin |
Diclofenac |
Etodolac |
Fenoprofen |
Floctafenine (available outside of the United States) |
Flurbiprofen |
Ibuprofen |
Indomethacin |
Ketoprofen |
Ketorolac |
Meclofenamate |
Mefenamic acid |
Naproxen |
Oxaprozin |
Piroxicam |
Sulindac |
Tiaprofenic acid (available outside of the United States) |
Nonopioid analgesics and nonacetylated salicylates that are poor inhibitors of COX-1 and only with higher concentrations of drug; cross-reactions with higher doses |
Acetaminophen (paracetamol) |
Diflunisal |
Salsalate |
Bismuth subsalicylate, bismuth salicylate (NOTE: Absorption of salicylate occurs from oral bismuth salicylates [eg, as used for treatment of diarrhea and other gastrointestinal complaints]) |
NSAIDs that preferentially inhibit COX-2 but also inhibit COX-1 when higher doses given; cross-reactions with higher doses |
Meloxicam |
Nabumetone |
Nimesulide (available outside of the United States) |
Highly selective COX-2 inhibitors that do not inhibit COX-1; cross-reactions are rare (may occur at the highest doses) |
Celecoxib |
Etoricoxib (available outside of the United States) |
Parecoxib (parenteral; available outside of the United States) |
Lumiracoxib (limited availability outside of the United States) |
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