Left panel: Mixed cellularity variant. The characteristic background infiltrate of reactive cells (eosinophils, lymphocytes) and uninucleate Reed-Sternberg cells is present in this field (red arrow). Right panel: Lymphocyte depletion variant. Diffuse fibrosis is seen, and a diagnostic binucleate Reed-Sternberg cell is present (blue arrow).
From: Warnke RA, Weiss LM, Chan JK, et al. Tumors of the lymph nodes and spleen. Atlas of tumor pathology (electronic fascicle), Third series, fascicle 14, 1995, Washington, DC. Armed Forces Institute of Pathology.