Mediation of thyroid hormone action

In the absence of T3, TR heterodimerizes with RXR, binds to a TRE and recruits CoR, resulting in gene silencing.

CoR: co-repressor; RXR: retinoid X receptor; TR: thyroid hormone receptor; TRE: thyroid hormone response element; T3: triiodothyronine.

Modified from: Refetoff S, Weiss RE. Resistance to thyroid hormone. In: Molecular Genetics of Endocrine Disorders, Thakker TV (Ed), Chapman & Hill, London, 1997, p.89.