Weeks | Agents | Dose | Days |
Induction MAP (weeks 1 through 10) | |||
1, 6 | Doxorubicin | 37.5 mg/m2 per day by continuous IV infusion or IV push | 1 and 2 |
Cisplatin | 60 mg/m2 per day IV over four hours | 1 and 2 | |
4, 5, 9, 10 | High-dose methotrexate | 12 grams/m2 IV over four hours* | 1 |
Leucovorin rescue | 15 mg (approximately 10 mg/m2) every six hours IV or orally for 10 doses¶ | Starting 24 hours after beginning high-dose methotrexate | |
Surgery (week 11) | |||
11 | Resection or amputation | ||
Postoperative MAP (weeks 12 through 29) | |||
12, 17 | DoxorubicinΔ | 37.5 mg/m2 per day by continuous IV infusion or IV push | 1 and 2 |
Cisplatin | 60 mg/m2 per day IV over four hours | 1 and 2 | |
22, 26 | DoxorubicinΔ | 37.5 mg/m2 per day IV over 24 hours | 1 and 2 |
15, 16, 20, 21, 24, 25, 28, 29 | High-dose methotrexate | 12 grams/m2 IV over four hours | 1 |
Leucovorin rescue | 15 mg (approximately 10 mg/m2) every six hours IV or orally for 10 doses | Starting 24 hours after beginning high-dose methotrexate |
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