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Early events in T cell receptor signal transduction

Early events in T cell receptor signal transduction
After antigen binds the TCR, Lck is activated and phosphorylates tryosine residues within the ITAMs of the CD3 and zeta chains, allowing ZAP-70 to be recruited to the TCR. Once ZAP-70 binds the phosphorylated ITAMs, it is phosphorylated by Lck, triggering all downstream signaling events required for T cell activation.
TCR: T cell receptor; APC: antigen presenting cell; MHC: major histocompatibility complex; ITAMs: immunoreceptor tyrosine-based activation motifs; CD: cluster of differentiation; Lck: lymphocyte cell-specific protein tyrosine kinase; ZAP-70; zeta chain-associated protein kinase 70.
Graphic 62164 Version 4.0

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