Seminomas |
Good risk |
All of the following: |
Any primary site |
No metastases to organs other than the lungs and/or lymph nodes |
Normal serum AFP |
Intermediate risk |
All of the following: |
Any primary site |
Metastases to organs other than the lungs and/or lymph nodes |
Normal serum AFP |
Nonseminomatous germ cell tumors |
Good risk |
All of the following: |
Testicular or retroperitoneal primary tumors |
No metastases to organs other than the lungs and/or lymph nodes |
Serum AFP <1000 ng/mL, beta-hCG <5000 milli-international units/mL, and LDH <3 times the upper limit of normal* |
Intermediate risk |
All of the following: |
Testicular or retroperitoneal primary tumors |
No metastases to organs other than the lungs and/or lymph nodes |
Serum AFP 1000 to 10,000 ng/mL* or |
Serum beta-hCG 5000 to 50,000 milli-international units/mL* or |
LDH 3 to 10 times the upper limit of normal* |
Poor risk |
Any of the following: |
Mediastinal primary with or without metastases |
Metastases to organs other than the lungs and/or lymph nodes |
Serum AFP >10,000 ng/mL* |
Serum beta-hCG >50,000 milli-international units/mL* |
LDH more than 10 times the upper limit of normal* |
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