Drug/formulation | Dosing recommendations for prophylaxis | ||||
Oseltamivir (Tamiflu)*
| 1 through 12 years | ≥13 years | |||
≤15 kg | >15 to 23 kg | >23 to 40 kg | >40 kg | 75 mg orally once daily | |
30 mg orally once daily | 45 mg orally once daily | 60 mg orally once daily | 75 mg orally once daily | ||
ZanamivirΔ (Relenza)
| Children ≥5 years and adults | ||||
| |||||
Baloxavir (Xofluza) for postexposure prophylaxis◊
| Children ≥5 years and adults§ | ||||
|
* Dose adjustment is necessary for patients with decreased or decreasing glomerular filtration rate.
¶ When dispensing the oral suspension of oseltamivir, pharmacists or other health care personnel should provide an oral syringe that can accurately measure the prescribed milliliter (mL) dose.
Δ Zanamivir inhalation powder should not be reconstituted in any liquid formulation and is not recommended for use in nebulizers or mechanical ventilators.
◊ Avoid administering baloxavir with milk, other dairy, antacids, or mineral supplements (eg calcium, iron, magnesium), which can significantly decrease oral bioavailability[2].
§ Baloxavir is available in Japan for postexposure prophylaxis in children <12 years of age who weigh >20 kg. Refer to Japanese prescribing information for dosing information for children <12 years of age.Do you want to add Medilib to your home screen?