A: Acute rejection*: characterized by perivascular and interstitial mononuclear cell infiltrates |
Grade 0: none |
Grade 1: minimal |
Grade 2: mild |
Grade 3: moderate |
Grade 4: severe |
B: Airway inflammation (lymphocytic bronchiolitis)*: characterized by mononuclear cell infiltrates in the submucosa of bronchioles |
Grade 0: none |
Grade 1R¶: low grade |
Grade 2R¶: high grade |
Grade X: ungradeable |
C: Chronic airway rejection (bronchiolitis obliterans): manifest by fibrous scarring that is often dense and eosinophilic |
0: absent |
1: present |
D: Chronic vascular rejection - accelerated graft vascular sclerosis: characterized by fibrointimal thickening of the pulmonary arteries and veins. These lesions are not seen on TBB as they affect larger blood vessels than those accessed with TBB. |
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