Receptor | Ligands | Cell expression | Signaling intermediates | Products |
TLR1 + TLR2 | Triacyl lipopeptide (Gram-positive bacteria, mycobacteria), Neisseria porins, Borrelia burgdorferi OspA | M/M, MDC | TIRAP, MyD88 | IC |
TLR2 + TLR6 | Diacyl lipopeptide | M/M, MC | TIRAP, MyD88 | IC |
TLR3 | dsRNA (viruses) | B, T, NK | TRIF | IC, type 1 IFN |
TLR4 | LPS (Gram-negative bacteria), RSV fusion protein, Chlamydia hsp60, extracellular matrix | M/M, MDC, MC | TRAM, TRIF or TIRAP, MyD88 | IC, type 1 IFN |
TLR5 | Flagellin (bacteria) | M/M, MDC | MyD88 | IC |
TLR7 | ssRNA (viruses), imidazoquinolines | M/M, MDC, PDC, B | MyD88 | IC, type 1 IFN |
TLR8 | ssRNA (viruses), imidazoquinolines | M/M, MDC, MC | MyD88 | IC, type 1 IFN |
TLR9 | CpG DNA (bacteria) | M/M, PDC, B, T | MyD88 | IC, type 1 IFN |
TLR10 | (unknown) | M/M, B | MyD88 |
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