Property | Internal mammary artery | Saphenous vein |
Anatomic | ||
Endothelial fenestrations | Few | Many |
Intercellular (IC) processes | Many | Few |
IC junction permeability | Low | High |
Internal elastic lamina (IEL) | Well defined | Poorly defined |
Heparan sulfate in IEL/media | High | Low |
Dependence on vasa vasorum | Minimal | High |
Valves | Absent | Present |
Size match with grafted native vessel | Good | Poor |
Resistance to trauma of harvesting | High | Low |
Physiologic | ||
Flow reserve | High | Low |
Shear stress | High | Low |
Nitric oxide/prostacyclin production | High | Low |
Vasomotor response to thrombin | Relaxation | Constriction |
Vasoconstrictor sensitivity | Low | High |
Vasodilator sensitivity | High | Low |
Basic fibroblast growth factor receptors | Few | Many (8xIMA) |
Lipolysis | Rapid | Slow |
Lipid synthesis | Less active | More active |
Lipid uptake | Slow | Rapid |
Oxidative stress | Low | High |
Do you want to add Medilib to your home screen?