MD Anderson* | Sokal et al¶ | WHOΔ |
PB blasts ≥15% PB blasts + pro ≥30% | PB or BM blasts ≥5% | PB or BM blasts 10 to 19% |
PB baso ≥20% | PB basophils ≥20% | PB basophils ≥20% |
Platelets <100,000/microL not related to therapy | Thrombocytopenia, not related to therapy | Platelets <100,000/microL, unrelated to therapy |
Cytogenetic evolution | Cytogenetic evolution | Cytogenetic evolution or additional clonal chromosomal abnormalities in Ph+ cells at diagnosis that include "major route" abnormalities, complex karyotype, or abnormalities of 3q26.2 |
Platelets >1 million/microL despite adequate therapy | Platelets >1,000,000/microL unresponsive to therapy | |
Marrow collagen fibrosis | ||
Anemia, unrelated to Rx | ||
Progressive splenomegaly | Progressive splenomegaly and increasing WBC unresponsive to therapy | |
WBC doubling time <5 days | ||
Unexplained fever | ||
Pelger-Huett-like neutrophils, nucleated RBCs, megakaryocyte fragments |
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