Condition | Mechanism |
Thromboembolism:
| Intravascular thrombosis and fibrinolysis |
Inflammation:
| Activation of the acute inflammatory response and coagulation pathway, intravascular thrombosis and fibrinolysis |
Surgery/trauma | Tissue ischemia, tissue necrosis |
Liver disease | Reduced clearance of fibrin degradation products |
Kidney disease | Multiple, including renal vein thrombosis and nephrotic syndrome |
Vascular disorders:
| Intravascular thrombosis and fibrinolysis |
Malignancy | Multiple, including vascular abnormalities, cancer procoagulant, and microvascular thrombosis |
Thrombolytic therapy | Fibrin breakdown |
Pregnancy:
| Physiologic changes in the coagulation system Microvascular thrombosis and fibrin deposition |
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