Treatment of Paget disease of the breast with breast conserving surgery and radiation

Study	N	Presentation	Treatment	Local Recurrence	Median F/U (mos)
Fourquet A; 1987	17	No mass Normal mammogram	Biopsy + radiation	3 (18 percent)	90
Bulens P; 1990	13	No mass	Biopsy + radiation	0 (0 percent)	52
Stockdale AD; 1989	19	No mass Normal mammogram	Biopsy + radiation	3 (16 percent)	63
Stockdale AD; 1989	6	No mass Abnormal/unknown mammogram	Biopsy + radiation	5 (8 percent)	63
Rissanen PM; 1969	8		Local surgery + radiation	3 (38 percent)
Bijker N; 2001	61	No mass, 97 percent Normal mammogram, 84 percent	Complete nipple-areolar resection + radiation	4 (6 percent)	77
Marshall JK; 2003	36	No mass Normal mammogram	Partial nipple-areolar resection + radiation (n = 9); complete nipple-areolar resection + radiation (n = 25)	4 (11 percent)	113

Fourquet A, Campana F, Vielh P, et al. Paget's disease of the nipple without detectable breast tumor: conservative management with radiation therapy. Int J Radiat Oncol Biol Phys 1987; 13:1463.
Bulens P, Vanuytsel L, Rijnders A, van der Schueren E. Breast conserving treatment of Paget's disease. Radiother Oncol 1990; 17:305.
Stockdale AD, Brierley JD, White WF, et al. Radiotherapy for Paget's disease of the nipple: a conservative alternative. Lancet 1989; 2:664.
Rissanen PM, Holsti P. Paget's disease of the breast: the influence of the presence or absence of an underlying palpable tumor on the prognosis and on the choice of treatment. Oncology 1969; 23:209.
Bijker N, Rutgers EJ, Duchateau L, et al. Breast-conserving therapy for Paget disease of the nipple: a prospective European Organization for Research and Treatment of Cancer study of 61 patients. Cancer 2001: 91:472.
Marshall JK, Griffith KA, Haffty BG, et al. Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results. Cancer 2003; 97:2142.

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