HBsAg | HBeAg | IgM anti-HBc | Total anti-HBc* | Anti-HBs | Anti-HBe | HBV DNA | ALT¶ | Interpretation |
Acute HBV infection | ||||||||
+ | + | + | ± | +++ | Elevated | Early phase | ||
+ | ± | + | Elevated | Window phase | ||||
+ | + | + | ± | Normal | Recovery phase | |||
Chronic HBV infection (HBsAg-positive for >6 months) | ||||||||
+ | + | + | - | - | +++ (Serum HBV typically >1 million international units/mL) | Normal or mildly elevated | Immune-tolerant phaseΔ | |
+ | + | + | - | - | +++ (Serum HBV >20,000 international units/mL) | Persistently elevated | Immune-active, HBeAg-positive◊ | |
+ | - | + | - | + | ++ (Serum HBV >2000 international units/mL) | Elevated | Immune-active, HBeAg-negative◊ | |
+ | - | + | + | - to ++ (Serum HBV ≤2000 international units/mL) | Normal or mildly elevated | Inactive chronic HBV§ | ||
- | - | ± (generally +) | ± | ± | + in liver; - to + in serum | Normal | Occult HBV |
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