Syndrome/disease | Responsible gene | Mode of acquisition |
FAP | APC | Germline (inherited) |
HNPCC (Lynch syndrome) | MMR genes | |
hMSH2 | ||
hMLH1 | ||
hPMS1 | ||
hPMS2 | ||
hMSH3 | ||
hMSH6 | ||
EPCAM (epigenetic alteration) | ||
Sporadic tumor | Tumor suppressor genes | Somatic (acquired) |
TP53 | ||
DCC | ||
APC | ||
Oncogenes | ||
MYC | ||
RAS | ||
SRC | ||
HER2 | ||
MMR genes (epigenetic change) |
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