There should be at least three relatives with any Lynch syndrome-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis) |
One should be a first-degree relative of the other two |
At least two successive generations should be affected |
At least one should be diagnosed before age 50 |
Familial adenomatous polyposis should be excluded in the colorectal cancer case(s), if any |
Tumors should be verified by pathological examination |
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