Abnormality | Causes |
Pregnancy | |
Anatomic abnormalities | |
Congenital abnormality in müllerian development* | Isolated defect |
Androgen insensitivity syndrome | |
5-alpha-reductase deficiency | |
Congenital defect of urogenital sinus development* | Agenesis of lower vagina |
Imperforate hymen | |
Intrauterine adhesions | Asherman syndrome |
Tuberculous endometritis | |
Disorders of the hypothalamic-pituitary-ovarian axis¶ | |
Hypothalamic dysfunction | |
Pituitary dysfunction | |
Ovarian dysfunction | Gonadal dysgenesis
|
Other causes of primary ovarian insufficiency | |
Polycystic ovary syndrome (PCOS) |
* Present as primary amenorrhea only.
¶ Refer to UpToDate graphics on the multiple causes of hormonal dysfunction.
Δ Turner syndrome (TS): Most females with TS present with primary amenorrhea. However, some present with secondary amenorrhea, typically those with mosaicism (most commonly 45,X/46,XX).
◊ 46,XY gonadal dysgenesis presents with primary amenorrhea only.Do you want to add Medilib to your home screen?