Antigen | ANA staining pattern | Approximate frequency in all patients (%) | Clinical associations | Organ involvement |
Scl-70 (topoisomerase-1) | Speckled | 10 to 40 | dcSSc | Lung fibrosis, isolated pulmonary hypertension less likely |
Centromere | Centromere (kinetochore) | 15 to 40 | lcSSc | Pulmonary hypertension, esophageal disease, "protection" from lung fibrosis and kidney disease |
RNA polymerase III | Fine speckled nucleolar | 4 to 25 | dcSSc | Kidney, skin, malignancy |
U3 RNP (fibrillarin) | Nucleolar | 1 to 5 | dcSSc, poor outcome, Black males | Pulmonary hypertension, muscle |
PM-Scl | Nucleolar | 3 to 6 | Overlap, mixed | Muscle |
U1 RNP | Speckled | 5 to 35 | lcSSc, Black patients, polymyositis overlap | Muscle |
Th/To | Nucleolar | 1 to 7 | lcSSc | Pulmonary hypertension, lung fibrosis, small bowel |
Anti-U11/U12 | Nucleolar | 1 to 5 | lcSSc and dcSSc | Lung fibrosis |
Anti-Ku | 1 to 3 | Overlap SSc | Muscle and joint involvement, SLE overlap |
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