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Causes of vitamin D deficiency or resistance

Causes of vitamin D deficiency or resistance
Deficient intake or absorption
Dietary
Malabsorption
Gastric bypass (bariatric surgery, gastrectomy)
Small bowel disease
Pancreatic insufficiency
Decreased skin synthesis
Inadequate sunlight exposure
Full sunscreen use
Darkly pigmented skin
Defective 25-hydroxylation
Cirrhosis
Obesity (possibly)
Increased catabolism of vitamin D to inactive metabolites
Antiseizure medications
Loss of vitamin D binding protein
Nephrotic syndrome
Defective 1-alpha 25-hydroxylation
Hypoparathyroidism
Kidney failure
1-alpha hydroxylase deficiency (vitamin D-dependent rickets, type 1)
Defective target organ response to calcitriol
Hereditary vitamin D-resistant rickets (vitamin D-dependent rickets, type 2)
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