One of the following: |
• A proband who has: |
- A tumor belonging to the LFS tumor spectrum (soft tissue sarcoma, osteosarcoma, premenopausal breast cancer, brain tumor, adrenocortical carcinoma, leukemia, or lung bronchoalveolar cancer) before age 46 years AND |
- At least 1 first- or second-degree relative with an LFS tumor (except breast cancer if the proband has breast cancer) before age 56 years or with multiple tumors; |
• A proband with multiple tumors (except multiple breast tumors), 2 of which belong to the LFS tumor spectrum and the first of which occurred before age 46 years; |
• A proband who is diagnosed with adrenocortical carcinoma or choroid plexus tumor, irrespective of family history |
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