FISH analysis for t(11;14)

FISH analysis for t(11;14) using a colocalization assay. A normal signal would show two red probes, localizing to the two alleles of the CCND1 gene on chromosome 11 and two green probes localizing to the IGH gene on chromosome 14. In this case of a t(11;14) translocation, the red and green probes are brought in close proximity.

FITC: fluorescein isothiocyanate.

Reproduced with permission from: Armitage JO, Mauch PM, Harris NL, et al. Non-Hodgkin Lymphomas, 2nd ed, Lippincott Williams & Wilkins, Philadelphia 2010. Copyright © 2010 Lippincott Williams & Wilkins. www.lww.com.

Graphic 58342 Version 10.0

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FISH analysis for t(11;14)