Adverse event | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
Infusion related reaction | Mild transient reaction; infusion interruption not indicated; intervention not indicated | Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (eg, antihistamines, NSAIDs, narcotics [opioids], intravenous fluids); prophylactic medication indicated for less than or equal to 24 hours | Prolonged (eg, not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for other clinical sequelae | Life-threatening consequences; urgent intervention indicated | Death |
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