Version August 2025
| Class | Specific agents |
| COX-2 inhibitors |
|
| HIV and HCV protease inhibitors¶ |
|
| Loop diuretics |
|
| Carbonic anhydrase inhibitors |
|
| Sulfonylurea hypoglycemics |
|
| Thiazide and related diuretics |
|
| Triptans |
(Other available triptans are not sulfonamides) |
| Other |
|
This table lists sulfonamide nonantimicrobial drugs; it is intended for use in conjunction with UpToDate content on sulfonamide hypersensitivity.
There are two groups of sulfonamide drugs: the antimicrobials and the nonantimicrobials. The two groups are structurally different, and patients who have had past reactions to sulfonamide antimicrobials, such as trimethoprim-sulfamethoxazole (cotrimoxazole, TMP-SMX) can receive sulfonamide nonantimicrobials safely.
NOTE: Despite evidence supporting lack of cross-reactivity, many US FDA labels for nonantimicrobial sulfonamides still contain warnings or contraindications concerning possible cross-reactions.
COX-2: cyclooxygenase 2; FDA: Food and Drug Administration; HCV: hepatitis C virus; HIV: human immunodeficiency virus.
* Not available commercially in the United States; available in other areas.
¶ The protease inhibitors darunavir, fosamprenavir, tipranavir, and simeprevir contain sulfonamide moieties but lack one or both essential functional groups implicated in sulfonamide antibiotic hypersensitivity. Thus, although they have antimicrobial functions, they are structurally members of the nonantimicrobial group, and patients allergic to sulfonamide antimicrobials can receive protease inhibitors normally.
