Definition of multiple myeloma |
Clonal bone marrow plasma cells ≥10% or biopsy-proven bony or extramedullary plasmacytoma* and any one or more of the following myeloma-defining events: |
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Definition of smoldering multiple myeloma |
Both criteria must be met: |
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Definition of monoclonal gammopathy of undetermined significance |
All three criteria must be met: |
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PET-CT: 18F-fluorodeoxyglucose positron emission tomography with computed tomography.
* Clonality should be established by showing kappa/lambda-light-chain restriction on flow cytometry, immunohistochemistry, or immunofluorescence. Bone marrow plasma cell percentage should preferably be estimated from a core biopsy specimen; in case of a disparity between the aspirate and core biopsy, the highest value should be used.
¶ Measured or estimated by validated equations.
Δ If bone marrow has less than 10% clonal plasma cells, more than one bone lesion is required to distinguish from solitary plasmacytoma with minimal marrow involvement.
◊ These values are based on the serum Freelite assay (The Binding Site Group, Birmingham, UK). The involved free light chain must be ≥100 mg/L.
§ Each focal lesion must be 5 mm or more in size.Do you want to add Medilib to your home screen?