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Atypical features of juvenile idiopathic arthritis that should prompt consideration of leukemia*

Atypical features of juvenile idiopathic arthritis that should prompt consideration of leukemia*
Nocturnal pain that may cause waking
Severe pain, requiring opiate analgesia
Pain out of proportion to severity of arthritis
Systemic symptoms out of proportion to severity of arthritis
Nonarticular bone pain
Atypical_features_JIA.htm
* Particularly before the initiation of corticosteroid or cytotoxic therapy.
Adapted from Murray, MJ, Tang, T, Ryder, C, et al. BMJ 2004; 329:959.
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