Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) and classic Hodgkin lymphoma (HL): Morphologic and immunophenotypic features

	Classic HL	NLPHL
Pattern	Diffuse, interfollicular, nodular	Nodular, at least in part
Tumor cells	Diagnostic RS cells; mononuclear or lacunar cells	"L&H" or "popcorn" cells
Background	Lymphocytes, histiocytes, eosinophils, plasma cells	Lymphocytes, histiocytes
Fibrosis	Common	Rare
CD15	+	-
CD30	+	-
CD20	-/+	+
CD45	-	+
EMA	-	+
EBV (in RS cells)	+ (∼50%)	-
Oct2	-/+	+
BOB.1	-/+	+
Background lymphocytes	T cells > B cells	B cells > T cells
CD57+ Tcells	-	+
Ig genes (single-cell PCR)	Rearranged, clonal, mutated, "crippled", no ongoing somatic hypermutation	Rearranged, clonal, mutated, productive, ongoing somatic hypermutation

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