Major criterion | Proximal sclerosis/induration of the skin | |
Minor criteria | Skin | Sclerodactyly |
Vascular | Raynaud phenomenon | |
Nailfold capillary abnormalities | ||
Digital tip ulcers | ||
Gastrointestinal | Dysphagia | |
Gastroesophageal reflux | ||
Renal | Renal crisis | |
New-onset arterial hypertension | ||
Cardiac | Arrhythmias | |
Heart failure | ||
Respiratory | Pulmonary fibrosis (seen on HRCT or radiograph of the chest) | |
DLCO | ||
Pulmonary hypertension | ||
Musculoskeletal | Tendon friction rubs | |
Arthritis | ||
Myositis | ||
Neurologic | Neuropathy | |
Carpal tunnel syndrome | ||
Serology | Antinuclear antibodies | |
SSc selective autoantibodies (anticentromere, antitopoisomerase I, antifibrillarin, anti-PM/Scl, antifibrillin, or anti-RNA polymerase I or III) |
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