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Version October 2024
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Clinical distinction between rheumatoid arthritis and osteoarthritis
Clinical distinction between rheumatoid arthritis and osteoarthritis
Feature
Rheumatoid arthritis
Osteoarthritis
Primary joints affected
Metacarpophalangeal
Proximal interphalangeal
Distal interphalangeal
Carpometacarpal
Heberden's nodes
Absent
Frequently present
Joint characteristics
Soft, warm, and tender
Hard and bony
Stiffness
Worse after resting (eg, morning stiffness)
If present, worse after effort, may be described as evening stiffness
Laboratory findings
Positive RF
Positive anti-CCP antibody
Elevated ESR and CRP
RF-negative
Anti-CCP antibody-negative
Normal ESR and CRP
RF: rheumatoid factor; CCP: cyclic citrullinated peptide; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.
Graphic 57005 Version 6.0
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