Increased |
Collagen I and III mRNA and protein production |
Proteoglycan synthesis |
Fibronectin synthesis |
Prolyl and lysyl hydroxylase enzyme activity |
PDGF receptor expression |
Production of IL-1 and IL-6 |
Serum independent proliferation |
Surface expression and shedding of ICAM-1 |
Collagenase secretion |
Suceptibility to anti-Fas induced apoptosis |
Reduced |
Collagen I mRNA downregulation in collagen gel matrix culture |
Collagenase production |
Proliferative response to recombinant EGF, endothelin-1 |
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