Gene | Inheritance | Clinical characteristics |
HFE | AR | Classical hereditary hemochromatosis (HH) with low penetrance; clinical onset in adulthood. |
HJV (hemojuvelin) or HAMP (hepcidin) | AR | Juvenile hemochromatosis with complete penetrance and early age of iron overload (childhood or young adulthood), along with early onset of hypogonadism and cardiac complications. Liver disease is less prominent. |
TFR2 (transferrin receptor 2) | AR | Rare condition described in case reports. Clinically similar to HH but with onset in young adults. |
SLC40A1 (ferroportin) | AD | Variable dominant disorder:
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