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Intratumoral heterogeneity of well-differentiated neuroendocrine tumors metastatic to the liver based on the mean and highest Ki67 grades on whole-slide subsections

Intratumoral heterogeneity of well-differentiated neuroendocrine tumors metastatic to the liver based on the mean and highest Ki67 grades on whole-slide subsections
  Tumor grade Homogeneous
(n = 24, 53 percent)		 Heterogeneous
(n = 21, 47 percent)
Mean Ki67 G1 (82 percent) 22 (59 percent) 15 (41 percent)
G2 (18 percent) 2 (25 percent) 6 (75 percent)
Highest Ki67 G1 (49 percent) 22 (100 percent) 0 (0 percent)
G2 (51 percent) 2 (9 percent) 21 (91 percent)
The percentage of G1 or G2 cases is based on the total number of cases. The percentage of homogeneous or heterogeneous cases in G1 (low grade) or G2 (intermediate grade) group is based on the number of cases in that particular grade.
Reproduced with permission from: Yang Z, Tang LH, Klimstra DS. Effect of tumor heterogeneity on the assessment of Ki67 labeling index in well-differentiated neuroendocrine tumors metastatic to the liver: implications for prognostic stratification. Am J Surg Pathol 2011; 35:853. Copyright © 2011 Lippincott Williams & Wilkins.
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