Category | Definition |
Suspected | An infant who does not meet the criteria for a probable or confirmed case (as defined below) but who has ≥1 of the following clinical findings of CRS:
|
Probable | Either |
An infant who does not have laboratory evidence of CRI (as defined below) but has ≥2 of the following clinical findings, without a more plausible etiology:
| |
OR | |
An infant who does not have laboratory evidence of CRI (as defined below) but has ≥1 of the following clinical findings, without a more plausible etiology:
Plus ≥1 of the following clinical findings:
| |
Confirmed | An infant with both:
Plus
|
Infection only | An infant without any clinical findings of CRS (listed above) but with laboratory evidence of CRI (as defined above)Δ |
CRS: congenital rubella syndrome; PDA: patent ductus arteriosus; PPS: peripheral pulmonary artery stenosis; CRI: congenital rubella infection; IgM: immunoglobulin M; IgG: immunoglobulin G; PCR: polymerase chain reaction; CDC: Centers for Disease Control and Prevention.
* In probable cases, if the infant has both eye-related findings (cataracts and congenital glaucoma), they should be considered as a single finding.
¶ Infants with clinical findings of CRS who test negative soon after birth should be retested later in infancy. Approximately 20% of infected infants tested for rubella IgM may not have detectable titers before age one month.
Δ In cases classified as infection only, if any compatible clinical finding (eg, hearing loss) is identified later, the case is reclassified as confirmed.Do you want to add Medilib to your home screen?