Central nervous system (CNS) infection |
Encephalitis and/or meningitis of unknown etiology |
Untreated or incompletely treated encephalitis and/or meningitis |
Herpes simplex encephalitis |
History of JC virus infection |
West Nile virus infection or other active arbovirus infection |
Cryptococcal infection of any site (or other disseminated fungal infection) |
Rabies |
Creutzfeld-Jacob disease |
Viral infection (also refer to CNS infections above) |
Acute viremia (eg, herpes simplex virus, cytomegalovirus, adenovirus, lymphocytic choriomeningitis virus, hepatitis A, West Nile virus) |
Active shingles (varicella-zoster infection) or herpes virus pneumonitis |
Acute Epstein-Barr virus (mononucleosis) |
HIV infection (serologic or molecular evidence)¶ |
Active hepatitis B or hepatitis C¶ |
Human T cell lymphotropic virus-I/-II (no longer an absolute contraindication in nonendemic regions) |
Severe acute respiratory syndrome coronavirus 2 |
Bacterial infection |
Active tuberculosis |
Untreated pneumonia |
Untreated bacterial or fungal sepsis (eg, candidemia) |
Untreated syphilis |
Multisystem organ failure due to overwhelming sepsis or gangrenous bowel |
Certain antimicrobial-resistant infections (relative contraindication) |
Parasitic infection |
Active Trypanosoma cruzi infection |
Active toxoplasmosis (prophylaxis effective) |
Leishmaniasis |
Strongyloidiasis (prophylaxis effective) |
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